2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15876
    Clopidogrel thiolactone 1147350-75-1 98.0%
    Clopidogrel thiolactone is an important intermediate in the metabolism of Clopidogrel (HY-15283). Clopidogrel thiolactone has antiplatelet aggregatione effects. Clopidogrel is a P2Y12 receptor inhibitor that exerts antiplatelet effects.
    Clopidogrel thiolactone
  • HY-18744
    FLT3-IN-2 923562-23-6 98.80%
    FLT3-IN-2 (Compound P-0266) is a FLT3 inhibitor with an IC50 of < 1 μM. FLT3-IN-2 can be used in acute myeloid leukemia research.
    FLT3-IN-2
  • HY-19254
    ZD-0892 171964-73-1
    ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.
    ZD-0892
  • HY-19354
    Aglafoline 143901-35-3 98.46%
    Aglafoline inhibits PAF-induced platelet aggregation, with an IC50 value of 50 μM.
    Aglafoline
  • HY-19431
    Ro 46-8443 175556-12-4 98.93%
    Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. Ro 46-8443 displays an at least 100-fold selectivity for ETB (IC50: 34-69 nM) over ETA receptors (IC50: 6800 nM).
    Ro 46-8443
  • HY-19661
    Tecadenoson 204512-90-3 99.69%
    Tecadenoson (CVT-510) is a selective A1 adenosine receptor agonist.
    Tecadenoson
  • HY-50291
    HOKU-81 58020-43-2
    HOKU-81 (4-Hydroxytulobuterol) is one of the metabolites of Tulobuterol (HY-B1810). HOKU-81 is a potent and selective β2-adrenoceptor stimulant. HOKU-81 has bronchodilating effect.
    HOKU-81
  • HY-A0275
    Amezinium methylsulfate 30578-37-1 99.77%
    Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake.
    Amezinium methylsulfate
  • HY-B0325
    Phenindione 83-12-5 98.21%
    Phenindione is an anticoagulant and can act as a vitamin K antagonist.
    Phenindione
  • HY-B0562
    Methyclothiazide 135-07-9 99.49%
    Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro.
    Methyclothiazide
  • HY-B1451
    Imidapril hydrochloride 89396-94-1 99.91%
    Imidapril hydrochloride (TA-6366) is an orally active dual inhibitor of angiotensin-converting enzyme (ACE) and MMP-9. Imidapril hydrochloride inhibits lipopolysaccharide-induced phosphorylation of c-Jun, MKK4 and JNK in monocytes, and downregulates the production of specific inflammatory factors such as TNF-α and IP-10, thereby exerting anti-inflammatory activity. Imidapril hydrochloride also effectively ameliorates mesangial expansion and reduces urinary albumin excretion by inhibiting angiotensin AngII production, lowering glomerular pressure and oxidative stress, thus delaying disease progression. Imidapril hydrochloride can also directly bind to the active site of MMP-9 to inhibit gelatinase activity, and suppress the enlargement of cerebral aneurysms without altering systemic blood pressure. Imidapril hydrochloride is widely applicable to related studies on autoimmune glomerulonephritis, diabetic nephropathy, cerebral aneurysms and other conditions.
    Imidapril hydrochloride
  • HY-B1587
    Carbazochrome 69-81-8 99.94%
    Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent.
    Carbazochrome
  • HY-N0320
    Salvianolic acid D 142998-47-8
    Salvianolic acid D is a depside. Salvianolic acid D can be isolated from Salvia miltiorrhiza (Danshen). Salvianolic acid D promotes the expression of Bcl-2, and inhibits the expressions of Bax, Cleaved caspase-3 and -9. Salvianolic acid D reduces the expression levels of TLR4, MyD88 and TRAF6 proteins both in vitro and in vivo, and significantly inhibits the nuclear translocation of NF-κB. Salvianolic acid D inhibits the cytoplasmic translocation of HMGB1. Salvianolic acid D suppresses inflammatory responses and alleviates cerebral ischemia-reperfusion injury. Salvianolic acid D serves as a potential antiplatelet active component.
    Salvianolic acid D
  • HY-N1400
    (20R)-Ginsenoside Rh1 80952-71-2 99.94%
    (20R)-Ginsenoside Rh1 is the R-isomer of Ginsenoside Rh1 (HY-N0604), and it is found in red ginseng, ginseng, and other sources. (20R)-Ginsenoside Rh1 inhibits thrombin-induced conversion of fibrinogen to fibrin, exerting anticoagulant and antithrombotic effects.
    (20R)-Ginsenoside Rh1
  • HY-N1403
    Tigogenin 77-60-1 98.0%
    Tigogenin is a steroidal sapogenins. Tigogenin can inhibit adipocytic differentiation and induce osteoblastic differentiation in mouse bone marrow stromal cells. Tigogenin can inhibit cells proliferation and induce apoptosis. Tigogenin can be used for the researches of cancer, inflammation, immunology, metabolic and cardiovascular disease, such as mammary gland carcinoma, rheumatoid arthritis, osteoporosis and atherosclerosis.
    Tigogenin
  • HY-N2005
    Cycleanine 518-94-5 99.80%
    Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway.
    Cycleanine
  • HY-N2439
    Methyl isoeugenol 93-16-3 98.11%
    Methyl isoeugenol is an orally active, blood-brain barrier-permeable isoeugenol-type eugenol analog. Methyl isoeugenol promotes the nuclear translocation of Nrf2, upregulates the expressions of HO-1, NQO1 and SOD, and reduces the expression level of MDA. Methyl isoeugenol decreases the nuclear translocation of NF-κB. Methyl isoeugenol inhibits NLRP3 inflammasome-mediated pyroptosis. Methyl isoeugenol reduces cerebral infarction volume and regulates the M1/M2 phenotypic balance of microglia. Methyl isoeugenol can be used for the research of cerebral ischemia-reperfusion injury.
    Methyl isoeugenol
  • HY-N3670
    Cycloolivil 3064-05-9 98.54%
    Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity. Antioxidant and Antiaggregant effects.
    Cycloolivil
  • HY-N3680
    Danshenxinkun A 65907-75-7 99.84%
    Danshenxinkun A is a natural compound that could be isolated from Tanshen and is used in the study for heart diseases.
    Danshenxinkun A
  • HY-N8251
    Cyclocurcumin 153127-42-5 99.48%
    Cyclocurcumin is a potent p38α inhibitor. Cyclocurcumin shows antirheumatic, antivasoconstrictive and antioxidant activities.
    Cyclocurcumin
Cat. No. Product Name / Synonyms Application Reactivity